Role of CD10 as a Prognostic Marker in Invasive Breast Carcinoma
Published: March 1, 2022 | DOI: https://doi.org/10.7860/JCDR/2022/51661.16063
Subitha Kandamuthan, Renu Thambi
1. Associate Professor, Department of Pathology, Government Medical College, Thrissur, Kerala, India.
2. Associate Professor, Department of Pathology, Government Medical College, Kottayam, India.
Correspondence
Subitha Kandamuthan,
Associate Professor, Department of Pathology, Government Medical College, Thrissur-680596, Kerala, India.
E-mail: subitha@rediffmail.com
Introduction: Stromal markers have been proved as important markers in assessing the prognosis of invasive breast cancer. Cluster of Differentiation (CD)10 is a cell surface enzyme with metalloendopeptidase activity which is expressed in stroma of various epithelial malignancies.
Aim: To estimate the expression of stromal CD10 expression in breast carcinoma and it’s association with other prognostic markers like Oestrogen Receptor (ER), Progesterone Receptor (PR), Human Epidermal growth factor Receptor 2 (HER2-neu), Ki-67and tumour grade.
Materials and Methods: This study was a hospital based cross-sectional study conducted on 50 cases of breast cancer received in histopathology laboratory of the Department of Pathology, Government Medical College, Kottayam during a period of two years from July 2015 to June 2017. Adequate representative sections were taken and Haematoxylin and Eosin (H&E) staining was done. Immunohistochemistry (IHC) of the tissue sections was done by ER, PR, HER2-neu, Ki-67 and CD10. Descriptive statistics was used for the presentation of data showing number and percentages. Mantel-Haenzel (MH) Chi-square test was used for finding the association between CD10 and other prognostic markers of breast carcinoma like ER, PR, HER2-neu and Ki-67.
Results: In this study, all patients were females with mean age of 57.26 years. CD10 was found associated with tumour grade with p-value=0.013. The association of CD10 with ER, PR, HER2-neu was statistically insignificant. Though the association of CD10 and Ki-67 was observed (MH Chi-square value was 0.015), but it was not statistically significant (p-value=0.903).
Conclusion: A statistically significant association of CD10 with increasing tumour grade was observed and the association of CD10 with ER, PR, HER2-neu and Ki-67 was not significant.
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